Volume 76, Issue 1 p. 1-8
Review

Complement

Paul A. Monach

Corresponding Author

Paul A. Monach

VA Boston Healthcare System and Harvard Medical School, Boston, Massachusetts

Address correspondence via email to Paul A. Monach, MD, PhD, at [email protected].

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First published: 08 August 2023

Author disclosures are available at https://onlinelibrary.wiley.com/doi/10.1002/art.42671.

Abstract

The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.