Volume 73, Issue 7 p. 1038-1040
Brief Report

Achievement of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Criteria for Systemic Lupus Erythematosus and Amount of Damage Accrual: Results From a Multiethnic Multicenter Cohort

Manuel F. Ugarte-Gil

Corresponding Author

Manuel F. Ugarte-Gil

Hospital Nacional Guillermo Almenara Irigoyen, EsSalud and Universidad Científica del Sur, Lima, Peru

Address correspondence to Manuel F. Ugarte-Gil, MD, MSc, School of Medicine, Universidad Cientifica del Sur, Lima, Peru, Avenida Panamericana Sur KM19, Villa El Salvador, Lima 15067, Peru. Email: [email protected].

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Guillermo J. Pons-Estel

Guillermo J. Pons-Estel

Hospital Provincial de Rosario, Rosario, and Grupo Oroño, Sanatorio Parque Rosario, Santa Fe, Argentina

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Russell Griffin

Russell Griffin

University of Alabama at Birmingham

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Luis M. Vilá

Luis M. Vilá

University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

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John D. Reveille

John D. Reveille

The University of Texas Health McGovern Medical School, Houston

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Graciela S. Alarcón

Graciela S. Alarcón

University of Alabama at Birmingham, and Universidad Peruana Cayetano Heredia, Lima, Peru

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First published: 15 April 2020
Citations: 9
No potential conflicts of interest relevant to this article were reported.

Abstract

Objective

To determine the difference in outcomes in patients who achieved or did not achieve the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria.

Methods

Patients from the LUpus in MInorities, NAture versus nurture (LUMINA) cohort were included. For these analyses, we compared those patients who achieved the 2019 EULAR/ACR criteria any time during follow-up to those who did not. The predefined outcomes were the last Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) scores and survival. Univariable and multivariable negative binomial regression models were performed; adjustment models were based on a forward selection process.

Results

In total, 98 of 640 patients never achieved the 2019 EULAR/ACR criteria. There was no difference in mean baseline SDI score among the patients who did not achieve the criteria compared to those who did. Conversely, the mean ± SD SDI score at last visit was lower for those who never achieved the criteria (1.2 ± 1.7 versus 2.0 ± 2.3, P = 0.0004). In the final adjusted model, the SDI score at last visit was 31% lower for those who never achieved the criteria (P = 0.0077). These patients were also more likely to survive, but this was not statistically significant.

Conclusion

In our cohort, patients who did not achieve the 2019 EULAR/ACR criteria accrued less damage, suggesting that these criteria could allow us to identify a subset of patients with more severe disease than allowed by previous criteria.